Long Life Study
7,875 WHI Extension Study participants between the ages of 63 and 99 years old participated in the WHI Long Life Study (LLS) in-person visits between March 2012 and May 2013. The eligible population for this project consisted of 14,081 women in the Medical Records Cohort who were at least 63 years old (by 12/1/11). Women were excluded if they resided in an institution (e.g., skilled nursing facility) or were unable to provide informed consent due to dementia. All participants have baseline biomarker data (glucose, insulin, CRP, creatinine, and lipids) and GWAS data. Please scroll down to see additional Long Life Study documentation.
The data and blood collected in the LLS establishes a new baseline from which numerous studies on aging and health/disease can be conducted. The data collection consisted of a brief clinical assessment and an assessment of functional status. The primary aims of the blood collection were to (1) establish a repository of new baseline biospecimen on this cohort, (2) replenish the WHI biospecimen resource for members of this cohort with a new source of good quality extracted DNA and RNA, plasma, serum, and RBCs for future standard clinical laboratory assays as well as cytokines, proteomics, metabolomics, and other assays that have yet to be imagined, and (3) obtain CBC data (e.g., hemoglobin, white blood cell count) and metabolic/CVD biomarker data (glucose, insulin, creatinine, CRP, and lipids). LLS data and biospecimen samples are available to researchers.
In addition to the main in-person visit that collected physical measurements, functional measurements, and blood, the WHI Long Life Study included two funded ancillary studies: OPACH and WHI-FI. While the LLS visits have been completed, the OPACH activities will continue with many participants through 2014. These ancillary studies are described below.
OPACH - Objective Physical Activity and Cardiovascular Health in Women (PI Andrea LaCroix; AS286)
The goals of this study are to increase understanding of the health of aging women – specifically the association of physical activity with cardiovascular events and total mortality. The eligible population for OPACH is identical to the LLS with one exception: OPACH excluded women who are non-ambulatory. The WHI LLS Consent form included information for both the main LLS in-person visit and OPACH. Participants who consented to LLS had the option of also consenting to OPACH. OPACH-specific activities include (1) wearing an accelerometer (physical activity monitor) for 1 week, (2) completing a Sleep Log for 1 week, (3) completing a Physical Activity Questionnaire, and (4) completing a Falls Calendar form every month for a year. OPACH activities will continue until one year after the last OPACH participant receives her OPACH 'kit'.
Two hundred OPACH participants completed an OPACH clinic visit (OPACH Calibration Study). The women eligible for the Calibration Study were separately consented.
WHI-Food Intake Study (WHI-FI) - Evidence for Establishing Optimum Protein Intake in Older Adults (PI Jeannette Beasley; AS340)
The WHI-FI Study also shares the LLS population. The LLS post-visit thank you letter packet introduced participants to the WHI-FI Study and requested that they complete a Food Frequency Questionnaire (FFQ). A total of 5,951 FFQs returned by LLS participants have been scanned.
WHI Long Life Study Documentation
: Section 5.4 of the WHI Extension Protocol includes the WHI Long Life Study, OPACH, and the WHI-FI Study. [This is the updated protocol
, IRB-approved in May 2012.]
Population Description: Every participant eligible for the WHI Long Life Study has baseline biomarkers (CRP, glucose, insulin, creatinine, and lipids) as well as GWAS data. [NOTE: Due to a lower than expected consent rate, the eligible population was increased by ~2600 women in May 2012 (Phase II) and again by 1500 in July/September 2012 (phase III).]
: For a description of the study, including a full explanation of OPACH, please refer to this PowerPoint Presentation.
Data to be Collected
: Please refer to this table for a synopsis of the data collected as part of the WHI Long Life Study.
: The Long Life Study consent request included a cover letter
and consent form
. The consent form covers both the WHI Long Life Study in-person visit and OPACH. (The OPACH Calibration Study has a separate consent form.)
Schedule: Long Life Study in-person visit appointments took place between March 2012 and May 2013. OPACH activities will continue for many participants through 2014.
: The WHI Long Life Study blood protocol was developed based on current literature and in consultation with laboratory experts. The attached document summarizes the blood protocol.
Blood Assays Available
on Long Life Study eligible participants: List of analytes which have been done by other studies on participants who are eligible to be in the Long Life Study.