Registration Now Open for the for the
2014 WHI Annual Investigator Meeting (3/7/14)
Please click here for registration information. The meeting will be held May 1-2, 2014, in Seattle, WA. Registrations will be accepted through Monday, April 28 at noon PT.
New WHI Data Release (2/28/14)
A new release of the WHI datasets was published February 28, 2014. New/updated data in this release include (1) adjudicated Heart Failure data from University of North Carolina (UNC) on just the HAH population (Hormone Trial/African American/Hispanic participant; Forms 135 and 136) and (2) the Short Physical Performance Battery scores among the Long Life Study participants (Form 301). A review of the supporting documentation, particularly the WHI Data Preparation and Use document, is recommended prior to using WHI data.
New WHI Data Release – Genetic Data Available (12-17-13)
The WHI investigator datasets were updated on December 17, 2013 with the addition of a new file that includes flags indicating which participants have genetic data available on dbGaP for the various WHI genetic studies, as well as case/control status and platform information. This file DOES NOT contain any actual genetic result data. This file can be used to help aid in determining number of participants available for a specific research project. Please refer to the GWAS & Biomarker Info page on the WHI website for more information. For information about the studies that produced the genetic data, please refer to the Study Site pages.
New WHI Data Release (12-5-13)
A new release of the WHI datasets was published December 4, 2013, and uploaded to this site on December 5, 2013. A review of the supporting documentation, particularly the WHI Data Preparation and Use document, is recommended prior to using WHI data.
NHLBI review of epidemiologic studies (7-11-13)
The NHLBI is undertaking an examination of the role and value of epidemiologic studies and pragmatic trials within their portfolio. Questions regarding optimal and efficient designs, the ability to leverage existing resources, and ethical considerations are being considered. As you can see from the note below, two of the NHLBI cohorts (Framingham and MESA) were given only limited funding (2 years at a much lower level) at their recent review, anticipating that future follow-up in these studies will be markedly different. WHI will undergo this same type of review over the next few weeks but the future structure and funding of all of these cohorts is up for discussion. Click on this link to Mike Lauer’s presentation on the topic, which will give you a sense of his perspective.
If you have thoughts about what the future of cardiovascular epidemiology should look like, now is the time to provide your comments. It would be helpful to have strong participation from people who understand the strengths and limitations of these studies, the investments that have already been made, what could still be gleaned, and what, if anything, might be trimmed without damaging these productive research enterprises.
American Diabetes Association and Eli Lilly and Company offer research funding opportunity (7-2-13)
The American Diabetes Association and Eli Lilly and Company announced a call for applications for original and innovative research proposals to further identify the safest and most effective means of diabetes treatment for the older adult population. Applications are due September 16, 2013. Click here for additional information
New WHI Data Release (6-3-13)
Several WHI investigator datasets were updated on May 31, 2013. Data added include computed variables for Form 155-LIfestyle Questionnaire, self-reports of angina and CHF in Extenstion Study 2005-2010 (ES1), and adjudicated CABG through 2012. See Data/WHI Data Available on This Site
for more details.
GWAS/CVD Biomarkers Cohort (3-1-13)
A set of approximately 22,300 WHI participants provide both GWAS and CVD biomarker data. Over half of these women are included in the Medical Record Cohort (MRC), with current collection and adjudication of outcomes. A subset of the MRC participants make up the Long Life Study, with additional data and blood collection. See summary tables on the Data/GWAS and Biomarkers Info page.
New WHI Data Release (2-1-13)
New WHI Datasets were published January 30, 2013.
PLEASE READ BEFORE DOWNLOADING DATA: The adjudication process changed considerably with the start of the second Extension Study in October 2010. Many events are no longer adjudicated in a large portion of the WHI participants. Please read the updated Data Preparation Document that explains in detail the changes before using these new outcomes datasets. There is a table on page 9 that summarizes the changes in adjudication.
Quick Links page added (1-18-13)
This new page (under For Researchers) provides quick links for those who are familiar with the WHI web site and want a quick way to find commonly used information without having to search the rest of the web site pages.
Updates to SharePoint site (12-21-12)
• Dietary data: MPEDs (MyPyramid Equivalents Database) and Healthy Eating Index 2005 (HEI-2005) data have been added as a single data set. Click here for details.
• Presentations: PowerPoint presentations from the May 3-4, 2012, Investigators meeting, the 2006 WHI Conference, and other study specific presentations have been added. See Presentations link in column at left.
• Propose a Study: the process for applying for and conducting ancillary studies are better described on the new Propose a Study pages.
Coming Bibliography Updates (Dec. 19, 2012)
We’ll be updating the Bibliography page to solely feature Excel and Advanced Search for WHI bibliographic searching. Excel snapshots can be downloaded and easily filtered to create concise listings. Everyone (logged in or not) can use the Excel snapshot feature. Excel can also be searched directly within SharePoint. For WHI site users logged on and who have manuscript privileges, the Excel table will have a new column with links to the full text for papers and approved proposals. The Advanced Search supports Boolean logic searching.
These changes will be implemented January 15, 2013.
Questions? Please contact the WHI Help Desk.
NHLBI FY 2013 Guidelines (Dec. 5, 2012)
See NHLBI’s FY 2013 Funding and Operating Guidelines now available on: http://www.nhlbi.nih.gov/funding/policies/operguid.htm.
WHI Progress Reports
(Nov. 21, 2012)
Several WHI Annual Progress Reports have been added to the WHI Data page (click here to see the list of reports). This includes the most recent report with data through Sept 2012. You may also be interested in the May 2010 report with data through the end of the Extension Study 2005-2010 and the 2005 report with data through the end of WHI 1993-2005.
Call for Papers (Nov. 14, 2012)
The journal Clinical Chemistry is planning a special edition on women's health, with a focus on biomarker research. Papers must be submitted by July 1, 2013 to be considered for this edition (which will be published in early 2014). See call for submissions.
Searchable list of variables (Nov. 13, 2012)
Looking for a particular data item and don’t know where to find it? Try the new Searchable list of dataset variables. The search function will help you locate the appropriate files for download.
New funding opportunity (Oct. 20, 2012)
NHLBI recently released an FOA for Publication of Secondary Dataset Analyses. The goal of this initiative is to support early-stage exploratory studies through analyses of existing datasets. Click here to see details.
Heart failure adjudication (Oct. 4, 2012)
Adjudication of all reports of heart failure in HT participants is scheduled to be completed by Sept. 1, 2013. This includes reports of heart failure through 2010, the end of Extension Study 2005-2010. All the adjudications will be done by UNC following similar coding used in ARIC.
Extensive release of blood lab results for Core, BAA, and Ancillary Studies (Sept. 4, 2012)
The Clinic CBC and Core Analyte results have been part of the investigators’ dataset for several years, and specimen results from the SHARe Cohort (Study ID #W54) were added in 2011. Today, assay results were added from the WHIMS-Plus Cohort (Study ID #W58) and Broad Agency Announcement Studies (BAAs or BAs)/Ancillary Studies (AS) with funding end dates before 8/31/11. See the updated Specimen Results. New assay data will be added to the dataset on an annual basis.
Check out the Specimen Results Descriptions. This database includes all of the assays currently available to approved investigators. You can search for the assay of your interest and learn a lot about the use of that assay with WHI specimens. The accompanying Specimen Results Read Me Documentation is filled with useful information, including how to use and interpret the Specimen Assay Result Database.
Extension Study 2010-2015 (ES2) Forms (Aug. 2, 2012):
Forms for the Extension Study 2 have been posted on the Documentation page under Forms.
Notice from the Steering Committee
In December, the WHI Steering Committee re-affirmed the policy that investigators may not use WHI participant lists as a recruitment source for other intervention studies. WHI participants can only be deliberately recruited into approved WHI Ancillary Studies.
New and updated data are now available for analysis
The Investigator data sets have been updated and/or made available on SharePoint under the data tab:
Form 150- Hormone Use Update, now with data through completion of Extension 1.
Form 151-Activities of Daily Life, now with all Extension 1 data and Extension 2 through September 16, 2011
Form 154 -Breast Health Supplement to the Medication Inventory contains data through completion of Extension 1.
Form 153–Medication and Supplement Inventory, now with data through completion of Extension 1.
Specimen Results-SHARe CVD Biomarkers study (i.e., lipids, glucose, insulin, CRP, creatinine, W54) are now available
Clarification of data sharing procedures for ancillary studies and BAAs
The WHI Steering Committee recently clarified the implementation of the Ancillary Study data ownership policy. As always, Ancillary Study (and BAA) investigators have the first right to publish the data that were generated by their projects. Once published, or after the funding has expired, the data are to be made available for other investigators through the Clinical Coordinating Center. The revision changes the implementation of the policy, as follows:
“A final analytic data set must be provided to the CCC at the time of the primary publication from the Ancillary Study. One year after the end of an Ancillary (or BAA) Study and without notifying the study’s PI, WHI may release data generated by the study to qualified scientific investigators requesting access through established WHI procedures. WHI will encourage the investigators requesting access to collaborate with the Ancillary Study or BAA PI who generated the data.”
This clarification was proposed to address implementation issues associated with the large, collaborative efforts where access was needed to similar data from several ancillary studies conducted over many years. The change is needed primarily to simplify this process. In almost all previous instances, WHI investigators have been able to develop productive collaborations where warranted. The difficulties have mostly arisen when we are not able to locate former PIs.
If you are a PI of an ancillary study or BAA, we encourage you to maximize your opportunity to collaborate in these studies by keeping the CCC informed of your contact information and staying engaged with the WHI. Also, if you have an ongoing study, please let the CCC know if your end-of-study date has changed since this affects when your data will be subject to release. For questions about this policy or submitting updated information or final analytic datasets, please contact Sue Mann (email@example.com).
Opportunities for scientific collaborations
WHI investigators have been busy! Click here to view some recent P&P stats. The P&P committee would like to congratulate the following writing groups for their publications appearing recently:
Ms152 - Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.Orchard TS, Larson JC, Alghothani N, Bout-Tabaku S, Cauley JA, Chen Z, Lacroix AZ, Wactawski-Wende J, Jackson RD. Am J Clin Nutr. 2014 Feb 5. [Epub ahead of print]
Ms1217 - Validity of diabetes self-reports in the Women's Health Initiative. Jackson JM, Defor TA, Crain AL, Kerby TJ, Strayer LS, Lewis CE, Whitlock EP, Williams SB, Vitolins MZ, Rodabough RJ, Larson JC, Habermann EB, Margolis KL. Menopause. 2014 Feb 3. [Epub ahead of print]
Ms683 - Educational attainment, MRI changes, and cognitive function in older postmenopausal women from the Women's Health Initiative Memory Study. Rapp S, Espeland M, Manson J, Resnick S, Bryan N, Smoller S, Coker L, Philips L, Stefanick M, Sarto G. International J Psychiatry in Medicine 46(2): 119-141, 2014.
Ms838 - Biomarker-calibrated protein intake and bone health in the Women’s Health Initiative clinical trial and observational study. Beasley JM1, Lacroix AZ, Larson JC, Huang Y, Neuhouser ML, Tinker LF, Jackson R, Snetselaar L, Johnson KC, Eaton CB, Prentice RL. Am J Clin Nutr. 2014 Feb 19. [Epub ahead of print]
Ms1634 - Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). Meyers KJ, Mares JA, Igo RP Jr, Truitt B, Liu Z, Millen AE, Klein M, Johnson EJ, Engelman CD, Karki CK, Blodi B, Gehrs K, Tinker L, Wallace R, Robinson J, Leblanc ES, Sarto G, Bernstein PS, Sangiovanni JP, Iyengar SK. Invest Ophthalmol Vis Sci. 2014 Jan 29;55(1):587-99. doi: 10.1167/iovs.13-13216.
Ms980 - Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA. Curr Gerontol Geriatr Res. 2013;2013:495793. doi: 10.1155/2013/495793. Epub 2013 Dec 22.
Ms1103 - Mediterranean and dietary approaches to stop hypertension dietary patterns and risk of sudden cardiac death in postmenopausal women. Bertoia ML, Triche EW, Michaud DS, Baylin A, Hogan JW, Neuhouser ML, Tinker LF, Van Horn L, Waring ME, Li W, Shikany JM, Eaton CB.. Am J Clin Nutr. 2014 Feb;99(2):344-51. doi: 10.3945/ajcn.112.056135. Epub 2013 Dec 18.
Ms1228 - Sedentary behavior and mortality in older women: the Women's Health Initiative. Seguin R, Buchner DM, Liu J, Allison M, Manini T, Wang CY, Manson JE, Messina CR, Patel MJ, Moreland L, Stefanick ML, Lacroix AZ. Am J Prev Med. 2014 Feb;46(2):122-35. doi: 10.1016/j.amepre.2013.10.021.
Ms1395 - Osteoporosis screening in women 50-64 years-old: Comparison of U.S. Preventive Services Task Force strategy and two traditional strategies in the Women’s Health Initiative. Crandall CJ, Larson J, Gourlay ML, Donaldson MG, Lacroix A, Cauley JA, Wactawski-Wende J, Gass ML, Robbins JA, Watts NB, Ensrud KE. J Bone Miner Res. 2014 Jan 16. doi: 10.1002/jbmr.2174. [Epub ahead of print]
Ms1414 - Change in brain and lesion volumes after CEE therapies: The WHIMS-MRI studies. Coker LH, Espeland MA, Hogan PE, Resnick SM, Bryan RN, Robinson JG, Goveas JS, Davatzikos C, Kuller LH, Williamson JD, Bushnell CD, Shumaker SA; For the WHIMS-MRI Study Group. Neurology. 2014 Jan 2. [Epub ahead of print]
Ms1562 - Nutrition and physical activity cancer prevention guidelines, cancer risk, and mortality in the Women’s Health Initiative. Thomson CA, McCullough ML, Wertheim B, Chlebowski RT, Martines ME, Stefanick ML, Rohan TE, Manson JE, Tindle HA, Ockene J, Vitolins MZ, Wactawski-Wende J, Sarto GE, Lane DS, Neuhouser ML. Cancer Prevention Research. 2014; 7:42-53. Ms1608 - Use of Medicare data to Identify coronary heart disease outcomes in the Women’s Health Initiative. Hlatky M, Ray RM, Burwen DR, Margolis K, Johnson KC, Kucharska-Newton A, Manson JE, Robinson JG, Safford MM, Allison M, Assimes T, Bavry A, Berger J, Cooper-DeHoff RM, Heckbert S, Li W, Liu S, Martin L, Perez M, Tindle H, Winkelmayer WC, Stefanick M. Circ Cardiovasc Qual Outcomes, 2014 Jan 7. doi: 10.1161/CIRCOUTCOMES.113.000373 [Epub ahead of print]
Ms1704 - Activity, energy intake, obesity, and the risk of incident kidney stones in postmenopausal women: a report from the Women's Health Initiative. Sorensen MD, Chi T, Shara NM, Wang H, Hsi RS, Orchard T, Kahn AJ, Jackson RD, Miller J, Reiner AP, Stoller ML. J Am Soc Nephrol. 2013 Dec 12. [Epub ahead of print]
Ms1295 - Cardiovascular disease and cognitive decline in postmenopausal women: results from the Women's Health Initiative Memory Study. Haring B, Leng X, Robinson J, Johnson KC, Jackson RD, Beyth R, Wactawski-Wende J, von Ballmoos MW, Goveas JS, Kuller LH, Wassertheil-Smoller S.. J Am Heart Assoc. 2013 Dec 18;2(6):e000369. doi: 10.1161/JAHA.113.000369.
Ms1951 - Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the Women's Health Initiative Observational Study cohort. Epigenetics. Bae S, Ulrich CM, Bailey LB, Malysheva O, Brown EC, Neuhouser ML, Cheng TY, Miller JW, Zheng Y, Xiao L, Hou L, Song X, Buck K, Beresford SA, Caudill MA. 2013 Dec 3;9(3). [Epub ahead of print]
Ms2031 - A Variational Bayes discrete mixture test for rare variant association. Logsdon, B. A., Dai, J. Y., Auer, P. L., Johnsen, J. M., Ganesh, S. K., Smith, N. L., Wilson, J. G., Tracy, R. P., Lange, L. A., Jiao, S., Rich, S. S., Lettre, G., Carlson, C. S., Jackson, R. D., O'Donnell, C. J., Wurfel, M. M., Nickerson, D. A., Tang, H., Reiner, A. P., Kooperberg, C. and on behalf of the NHLBI GO Exome Sequencing Project (2013),. Genet. Epidemiol.. Doi: 10.1002/gepi.21772 Ms1223 - The adipokine profile of metabolically benign obese and at-risk normal weight postmenopausal women: The Women’s Health Initiative Observational Study. Khan UI, Ogorodnikova AD, Xu L, Wang D, Wassertheil-Smoller S, Ho GY, Sowers MR, Rajpathak SN, Allison MA, Mackey RH, Vitolins MZ, Manson JE, Wildman RP. . Obesity (Silver Spring). 2012 Nov 6. doi: 10.1002/oby.20139. [Epub ahead of print]
Ms891 – Self-rated health and medical outcomes in the Women’s Health Initiative: The aging continuum, health, morbidity, mortality. Robert Brunner, Marcia L. Stefanick, Aaron K. Aragaki, Shirley A.A. Beresford, F. Allan Hubbell, Andrea LaCroix, Dorothy S. Lane, Stephen R. Rapp, Monika M. Safford, Nazmus Saquib, Nelson B. Watts and Nancy Fugate Woods. J Gerontol Geriat Res 3:139. doi: 10.4172/2167-7182.1000139. J.Gerontol Geriat Res 3:139. doi: 10.4172/2167-7182.1000139
Ms1389 - Biomarker-calibrated protein intake and physical function in the Women's Health Initiative. Beasley JM, Wertheim BC, Lacroix AZ, Prentice RL, Neuhouser ML, Tinker LF, Kritchevsky S, Shikany JM, Eaton C, Chen Z, Thomson CA. J Am Geriatr Soc. 2013 Nov;61(11):1863-71. doi: 10.1111/jgs.12503. Epub 2013 Oct 28.
Ms1391 - Obesity and the late-age survival without major disease or disability in older women. Rillamas-Sun E, Lacroix AZ, Waring ME, Kroenke CH, Lamonte MJ, Vitolins MZ, Seguin R, Bell CL, Gass M, Manini TM, Masaki KH, Wallace RB. JAMA Intern Med. 2013 Nov 11. [Epub ahead of print]
Ms1612 - Circulating soluble cytokine receptors and colorectal cancer risk. Ho GY, Wang T, Zheng SL, Tinker LF, Xu J, Rohan TE, Wassertheil-Smoller S, Xue X, Augenlicht LH, Peters U, Phipps AI, Strickler HD, Gunter MJ, Cushman M. Cancer Epidemiol Biomarkers Prev. 2013 Nov 5. [Epub ahead of print]
Ms1281 - Does CHA2DS2-VASc improve stroke risk stratification in postmenopausal women with atrial fibrillation. Abraham JM, Larson J, Chung MK, Curtis AB, Lakshminarayan K, Newman JD, Perez M, Rexrode K, Shara NM, Solomon AJ, Stefanick ML, Torner JC, Wilkoff BL, Wassertheil-Smoller S. Am J Med. 2013 Oct 17. pii: S0002-9343(13)00671-2. [Epub ahead of print]
Ms1661 - Multivitamin and mineral use and breast cancer mortality in older women with invasive breast cancer in the Women’s Health Initiative. Wassertheil-Smoller S, McGinn AP, Budrys N, Chlebowski R, Ho GY, Johnson KC, Lane DS, Li W, Neuhouser ML, Saquib J, Shikany JM, Song Y, Thomson C.. Breast Cancer Res Treat. 2013 Oct;141(3):495-505. Epub 2013 Oct 9.
Ms1152 - Mediterranean and DASH diet scores and mortality in women with heart failure: the Women’s Health Initiative. Levitan EB, Lewis CE, Tinker LF, Eaton CB, Ahmed A, Manson JE, Snetselaar LG, Martin LW, Trevisan M, Howard BV, Shikany JM. Circ Heart Fail. 2013 Oct 9. [Epub ahead of print]
Ms2057 - Phospholipase A2G1B polymorphisms and risk of colorectal neoplasia. Abbenhardt C, Poole EM, Kulmacz RJ, Xiao L, Curtin K, Galbraith RL, Duggan D, Hsu L, Makar KW, Caan BJ, Koepl L, Owen RW, Scherer D, Carlson CS; Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and CCFR, Potter JD, Slattery ML, Ulrich CM. Int J Mol Epidemiol Genet. 2013 Sep 12;4(3):140-9.
Ms1566 - Genetic predictors of circulating 25-hydroxyvitamin D and risk of colorectal cancer. Hiraki LT, Qu C, Hutter CM, Baron J, Berndt SI, Bezieau S, Brenner H, Caan BJ, Casey G, Chang-Claude J, Chanock SJ, Conti DV, Duggan D, Fuchs CS, Gallinger S, Giovannucci EL, Harrison TA, Hayes RB, Hazra A, Henderson B, Hoffmeister M, Hopper JL, Hudson TJ, Jenkins MA, Küry S, Le Marchand L, Lemire M, Ma J, Manson JE, Nan H, Newcomb PA, Ng K, Potter JD, Schoen RE, Schumacher F, Seminara D, Slattery ML, Wactawski-Wende J, White E, Wu K, Zanke BW, Kraft P, Peters U, Chan AT. Cancer Epidemiol Biomarkers Prev. 2013 Aug 27. [Epub ahead of print]
Ms1689 - Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia. Cheng I, Kocarnik JM, Dumitrescu L, Lindor NM, Chang-Claude J, Avery CL, Caberto CP, Love SA, Slattery ML, Chan AT, Baron JA, Hindorff LA, Park SL, Schumacher FR, Hoffmeister M, Kraft P, Butler AM, Duggan DJ, Hou L, Carlson CS, Monroe KR, Lin Y, Carty CL, Mann S, Ma J, Giovannucci EL, Fuchs CS, Newcomb PA, Jenkins MA, Hopper JL, Haile RW, Conti DV, Campbell PT, Potter JD, Caan BJ, Schoen RE, Hayes RB, Chanock SJ, Berndt SI, Küry S, Bézieau S, Ambite JL, Kumaraguruparan G, Richardson DM, Goodloe RJ, Dilks HH, Baker P, Zanke BW, Lemire M, Gallinger S, Hsu L, Jiao S, Harrison TA, Seminara D, Haiman CA, Kooperberg C, Wilkens LR, Hutter CM, White E, Crawford DC, Heiss G, Hudson TJ, Brenner H, Bush WS, Casey G, Le Marchand L, Peters U. Gut. 2013 Aug 9. [Epub ahead of print]
Ms1899 - Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative Randomized Trials. Manson JE, Chlebowski RT, Stefanick ML, Aragaki AK, Rossouw JE, Prentice RL, Anderson G, Howard BV, Thomson CA, Lacroix AZ, Wactawski-Wende J, Jackson RD, Limacher M, Margolis KL, Wassertheil-Smoller S, Beresford SA, Cauley JA, Eaton CB, Gass M, Hsia J, Johnson KC, Kooperberg C, Kuller LH, Lewis CE, Liu S, Martin LW, Ockene JK, O'Sullivan MJ, Powell LH, Simon MS, Van Horn L, Vitolins MZ, Wallace RB. JAMA. 2013 Oct 2;310(13):1353-1368.
Ms1130 - Hormone therapy dose, formulation, route of delivery, and risk of cardiovascular events in women: Findings from the WHI Observational Study Menopause. Shufelt CL, Merz CN, Prentice RL, Pettinger MB, Rossouw JE, Aroda VR, Kaunitz AM, Lakshminarayan K, Martin LW, Phillips LS, Manson JE. 2013 Sep 16. [Epub ahead of print]
Ms1563 - All-cause, cardiovascular, and cancer mortality rates in postmenopausal white, black, Hispanic, and Asian women with and without diabetes in the United States: The Women's Health Initiative. Ma Y, Hébert JR, Balasubramanian R, Wedick NM, Howard BV, Rosal MC, Liu S, Bird CE, Olendzki BC, Ockene JK, Wactawski-Wende J, Phillips LS, Lamonte MJ, Schneider KL, Garcia L, Ockene IS, Merriam PA, Sepavich DM, Mackey RH, Johnson KC, Manson JE. 1993-2009. Am J Epidemiol. 2013 Sep 17. [Epub ahead of print]
Ms1218 - Age, body mass, usage of exogenous estrogen, and lifestyle factors in relation to circulating sex hormone-binding globulin concentrations in postmenopausal women. Goto A, Chen BH, Song Y, Cauley J, Cummings SR, Farhat GN, Gunter M, Van Horn L, Howard BV, Jackson R, Lee J, Rexrode KM, Liu S. Clin Chem. 2013 Sep 18. [Epub ahead of print]
Ms1033 – Sex hormone levels and risk of breast cancer with estrogen plus progestin. Farhat G, Parimi N, Chlebowski RT; Manson JE, Anderson G, Huang AJ, Vittinghoff E, Lee JS, LaCroix AZ, Cauley JA, Jackson R, Grady R, Lane DS; Phillips L, Simon MS, Cummings SR. J Natl Cancer Inst. 2013 Sep 16. [Epub ahead of print]
Ms1438 - Prospective analysis of association between statin use and breast cancer risk in the Women's Health Initiative. Desai P, Chlebowski RT, Cauley JA, Manson JE, Wu C, Martin LW, Jay A, Bock CH, Cote ML, Petrucelli N, Rosenberg CA, Peters U, Agalliu I, Budrys N, Abdul-Hussein M, Lane DS, Luo J, Park HL, Thomas F, Wactawski-Wende J, Simon MS. Ms2025 - Generalization of adiposity genetic loci to US Hispanic women. Graff M, Fernández-Rhodes L, Liu S, Carlson C, Wassertheil-Smoller S, Neuhouser M, Reiner A, Kooperberg C, Rampersaud E, Manson JE, Kuller LH, Howard BV, Ochs-Balcom HM, Johnson KC, Vitolins MZ, Sucheston L, Monda K, North KE. Nutr Diabetes. 2013 Aug 26;3:e85. Ms1791 - Calcium plus vitamin D supplementation and joint symptoms in postmenopausal women in the Women’s Health Initiative randomized trial. Chlebowski RT, Pettinger M, Johnson KC, Wallace R, Womack C, Mossavar-Rahmani Y, Stefanick M, Wactawski-Wende J, Carbone L, Lu B, Eaton C, Walitt B, Kooperberg CL. J Acad Nutr Diet. 2013 Aug 14. pii: S2212-2672(13)00685-0. [Epub ahead of print]
Ms1791 - Calcium plus vitamin D supplementation and joint symptoms in postmenopausal women in the Women’s Health Initiative randomized trial. Chlebowski RT, Pettinger M, Johnson KC, Wallace R, Womack C, Mossavar-Rahmani Y, Stefanick M, Wactawski-Wende J, Carbone L, Lu B, Eaton C, Walitt B, Kooperberg CL. J Acad Nutr Diet. 2013 Aug 14. pii: S2212-2672(13)00685-0. [Epub ahead of print] Ms1361 - Change in physical activity after a diabetes diagnosis: Opportunity for intervention. Schneider KL, Andrews C, Hovey KM, Seguin RA, Manini T, Lamonte MJ, Margolis KL, Waring ME, Ning Y, Sims S, Ma Y, Ockene J, Stefanick ML, Pagoto SL. Med Sci Sports Exerc. 2013 Jul 15. [Epub ahead of print]
Ms1333 - Prestroke factors associated with poststroke mortality and recovery in older women in the Women's Health Initiative. Bell CL, Lacroix A, Masaki K, Hade EM, Manini T, Mysiw WJ, Curb JD, Wassertheil-Smoller S. J Am Geriatr Soc. 2013 Jul 19. [Epub ahead of print]
Ms1931 - No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women. Passarelli MN, Newcomb PA, Makar KW, Burnett-Hartman AN, Phipps AI, David SP, Hsu L, Harrison TA, Hutter CM, Duggan DJ, White E, Chan AT, Peters U. Menopause. 2013 Jul 22. [Epub ahead of print]
Ms1936 - Adult stature and risk of cancer at different anatomic sites in a cohort of postmenopausal women. Kabat GC, Anderson ML, Heo M, Hosgood HD 3rd, Kamensky V, Bea JW, Hou L, Lane DS, Wactawski-Wende J, Manson JE, Rohan TE. Cancer Epidemiol Biomarkers Prev. 2013 Jul 25. [Epub ahead of print]
Ms1283 - Investigation of Epstein-Barr virus as a potential cause of B-cell non-Hodgkin lymphoma in a prospective cohort. De Roos AJ, Martinez-Maza O, Jerome KR, Mirick DK, Kopecky KJ, Madeleine MM, Magpantay L, Edlefsen KL, Lacroix AZ. Cancer Epidemiol Biomarkers Prev. 2013 Jul 24. [Epub ahead of print]
Ms1613 - Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50-55 years. Espeland MA, Shumaker SA, Leng I, Manson JE, Brown CM, Leblanc ES, Vaughan L, Robinson J, Rapp SR, Goveas JS, Lane D, Wactawski-Wende J, Stefanick ML, Li W, Resnick SM; for the WHIMSY Study Group. JAMA Intern Med. 2013 Jun 24:1-8. [Epub ahead of print]
Ms1179 – Relations of depressive symptoms and antidepressant use to body mass index and selected biomarkers for diabetes and cardiovascular disease. Ma Y, Balasubramanian R, Pagoto SL, Schneider KL, Hébert JR, Phillips LS, Goveas JS, Culver AL, Olendzki BC, Beck J, Smoller JW, Sepavich DM, Ockene JK, Uebelacker L, Zorn M, Liu S. Relations of Depressive Symptoms and Antidepressant Use to Body Mass Index and Selected Biomarkers for Diabetes and Cardiovascular Disease. Am J Public Health. 2013 Jun 13. Ms1336 - Women's Health Initiative clinical trials: interaction of calcium and vitamin D with hormone therapy. Robbins JA, Aragaki A, Crandall CJ, Manson JE, Carbone L, Jackson R, Lewis CE, Johnson KC, Sarto G, Stefanick ML, Wactawski-Wende J. Menopause. 2013 Jun 24. [Epub ahead of print]
Ms1231 - Frequency of private spiritual activity and cardiovascular risk in postmenopausal women: the Women's Health Initiative. Salmoirago-Blotcher E, Fitchett G, Hovey KM, Schnall E, Thomson C, Andrews CA, Crawford S, O'Sullivan MJ, Post S, Chlebowski RT, Ockene J. Ann Epidemiol. 2013 May;23(5):239-45.
Ms1710 - Body fat and breast cancer risk in postmenopausal women: a longitudinal study. Rohan TE, Heo M, Choi L, Datta M, Freudenheim JL, Kamensky V, Ochs-Balcom HM, Qi L, Thomson CA, Vitolins MZ, Wassertheil-Smoller S, Kabat GC. J Cancer Epidemiol. 2013;2013:754815. Epub 2013 Apr 7.
Ms1368 - Racial/ethnic disparities in association between dietary quality and incident diabetes in postmenopausal women in the United States: the Women's Health Initiative 1993-2005. Qiao Y, Tinker L, Olendzki BC, Hébert JR, Balasubramanian R, Rosal MC, Hingle M, Song Y, Schneider KL, Liu S, Sims S, Ockene JK, Sepavich DM, Shikany JM, Persuitte G, Ma Y.hn Health. 2013 May 22. [Epub ahead of print]
Ms1557 – Genome-wide association study of serum selenium concentrations. Gong J, Hsu L, Harrison T, King IB, Stürup S, Song X, Duggan D, Liu Y, Hutter C, Chanock SJ, Eaton CB, Marshall JR, Peters U. Nutrients. 2013 May 21;5(5):1706-18.
Ms1552 - Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations. Coram MA, Duan Q, Hoffmann TJ, Thornton T, Knowles JW, Johnson NA, Ochs-Balcom HM, Donlon TA, Martin LW, Eaton CB, Robinson JG, Risch NJ, Zhu X, Kooperberg C, Li Y, Reiner AP, Tang H. Am J Hum Genet. 2013 May 29. pii: S0002-9297(13)00212-7. [Epub ahead of print]
Ms890 - Risk factors for atrial fibrillation and their population burden in postmenopausal women: the Women's Health Initiative Observational Study. Perez MV, Wang PJ, Larson JC, Soliman EZ, Limacher M, Rodriguez B, Klein L, Manson JE, Martin LW, Prineas R, Connelly S, Hlatky M, Wassertheil-Smoller S, Stefanick ML. Heart. 2013 Jun 11. [Epub ahead of print]
Ms1166 - Diabetes, metformin use, and colorectal cancer survival in postmenopausal women. Cossor FI, Adams-Campbell LL, Chlebowski RT, Gunter MJ, Johnson K, Martell RE, McTiernan A, Simon MS, Rohan T, Wallace RB, Paulus JK. Cancer Epidemiol. 2013 Jun 14. pii: S1877-7821(13)00075-1. [Epub ahead of print]
Ms1893 - A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, Yanek LR, Aldrich MC, Ademola A, Amos CI, Bandera EV, Bock CH, Britton A, Broeckel U, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chen WM, Chen F, Chen YD, Chiang CW, Coetzee GA, Demerath E, Deming-Halverson SL, Driver RW, Dubbert P, Feitosa MF, Feng Y, Freedman BI, Gillanders EM, Gottesman O, Guo X, Haritunians T, Harris T, Harris CC, Hennis AJ, Hernandez DG, McNeill LH, Howard TD, Howard BV, Howard VJ, Johnson KC, Kang SJ, Keating BJ, Kolb S, Kuller LH, Kutlar A, Langefeld CD, Lettre G, Lohman K, Lotay V, Lyon H, Manson JE, Maixner W, Meng YA, Monroe KR, Morhason-Bello I, Murphy AB, Mychaleckyj JC, Nadukuru R, Nathanson KL, Nayak U, N'diaye A, Nemesure B, Wu SY, Leske MC, Neslund-Dudas C, Neuhouser M, Nyante S, Ochs-Balcom H, Ogunniyi A, Ogundiran TO, Ojengbede O, Olopade OI, Palmer JR, Ruiz-Narvaez EA, Palmer ND, Press MF, Rampersaud E, Rasmussen-Torvik LJ, Rodriguez-Gil JL, Salako B, Schadt EE, Schwartz AG, Shriner DA, Siscovick D, Smith SB, Wassertheil-Smoller S, Speliotes EK, Spitz MR, Sucheston L, Taylor H, Tayo BO, Tucker MA, Van Den Berg DJ, Edwards DR, Wang Z, Wiencke JK, Winkler TW, Witte JS, Wrensch M, Wu X, Yang JJ, Levin AM, Young TR, Zakai NA, Cushman M, Zanetti KA, Zhao JH, Zhao W, Zheng Y, Zhou J, Ziegler RG, Zmuda JM, Fernandes JK, Gilkeson GS, Kamen DL, Hunt KJ, Spruill IJ, Ambrosone CB, Ambs S, Arnett DK, Atwood L, Becker DM, Berndt SI, Bernstein L, Blot WJ, Borecki IB, Bottinger EP, Bowden DW, Burke G, Chanock SJ, Cooper RS, Ding J, Duggan D, Evans MK, Fox C, Garvey WT, Bradfield JP, Hakonarson H, Grant SF, Hsing A, Chu L, Hu JJ, Huo D, Ingles SA, John EM, Jordan JM, Kabagambe EK, Kardia SL, Kittles RA, Goodman PJ, Klein EA, Kolonel LN, Le Marchand L, Liu S, McKnight B, Millikan RC, Mosley TH, Padhukasahasram B, Williams LK, Patel SR, Peters U, Pettaway CA, Peyser PA, Psaty BM, Redline S, Rotimi CN, Rybicki BA, Sale MM, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Strom SS, Thun MJ, Vitolins M, Zheng W, Moore JH, Williams SM, Ketkar S, Zhu X, Zonderman AB; NABEC Consortium; UKBEC Consortium; BioBank Japan Project; AGEN Consortium, Kooperberg C, Papanicolaou GJ, Henderson BE, Reiner AP, Hirschhorn JN, Loos RJ, North KE, Haiman CA. Nat Genet. 2013 Apr 14. [Epub ahead of print]
Ms1532- Factors relating to eating style, social desirability, body image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative. Mossavar-Rahmani Y, Tinker LF, Huang Y, Neuhouser ML, McCann SE, Seguin RA, Vitolins MZ, Curb JD, Prentice RL. Nutr J. 2013 May 16;12(1):63. [Epub ahead of print]
Ms1392- Self-perceived physical health predicts cardiovascular disease incidence and death among postmenopausal women.
Saquib N, Brunner R, Kubo J, Tindle H, Kroenke C, Desai M, Daviglus ML, Allen N, Martin LW, Robinson J, Stefanick ML. BMC Public Health. 2013 May 14;13(1):468. [Epub ahead of print]
Ms1183 - Walking speed, physical activity, and breast cancer in postmenopausal women. Kwan K, Chlebowski RT, McTiernan A, Rodabough RJ, La Monte MJ, Martin LW, Bell C, Lane DS, Kaplan RC, Irwin ML. Eur J Cancer Prev. 2013 May 10. [Epub ahead of print] Ms1509- The relationship of sedentary behavior and physical activity to incident cardiovascular disease: Results from the Women’s Health Initiative. Andrea K. Chomistek, JoAnn E. Manson, Marcia L. Stefanick, Bing Lu, Megan Sands-Lincoln, Scott B. Going, Lorena Garcia, Matthew A. Allison, Stacy T. Sims, Michael J. LaMonte, Karen C. Johnson, Charles B. Eaton. J Am Coll Cardiol. 2013 Apr 10. pii: S0735-1097(13)01404-6. doi: 10.1016/j.jacc.2013.03.031. [Epub ahead of print] Ms1887- The rationale, design, and baseline characteristics of the Women's Health Initiative Memory Study of Younger Women (WHIMS-Y). Vaughan L, Espeland MA, Snively B, Shumaker SA, Rapp S, Shupe J, Robinson J, Sarto GE, Resnick. Brain Res. 2013 Apr 8. pii: S0006-8993(13)00487-3. doi: 10.1016/j.brainres.2013.03.047. [Epub ahead of print] Ms1942- Performance of Multiplex Cytokine Assays in Serum and Saliva among Community-Dwelling Postmenopausal Women. Richard W. Browne mail, Alpdogan Kantarci, Michael J. LaMonte, Christopher A. Andrews, Kathleen M. Hovey, Karen L. Falkner, Ali Cekici,Danielle Stephens, Robert J. Genco, Frank A. Scannapieco, Thomas E. Van Dyke, Jean Wactawski-Wende.
Investigators not previously associated with WHI have the opportunity to use the WHI resource for scientific activities. The primary route involves collaborating with an existing WHI investigator who will serve as a sponsor, orienting a new investigator to both the data and specimen resources and to the process for obtaining access and approvals as well as participating in the scientific process. Potential sponsors may be found at WHI Investigators.
There are two basic types of activities that a researcher may pursue:
1) A manuscript proposal that seeks to analyze existing data,
2) An ancillary study, which proposes to collect additional data either directly from the participant or indirectly (e.g., from linkage to another dataset or through analysis of WHI biospecimens).
A description of the available data may be found at WHI data here and the biospecimen resource is described here. Manuscript proposals are reviewed by the WHI Publications and Presentations Committee (P&P) twice per month. Ancillary study proposals are reviewed by the Ancillary Study Committee monthly. Guidelines and forms for submission for each may be found under the link "Write a Paper" or "Propose a Study" on the left side of this page.
Before proposing either type of activity, it is advisable to review both approved manuscript proposals and current and completed studies to assure that no one else is already working on your topic.
Non-WHI investigators may also be interested in participating in one or more of WHI's Scientific Interest Groups (SIGs). The SIGs meet by conference call regularly to share information, stimulate ideas, and coordinate scientific activities in line with their mutual interests. You need not be a WHI investigator to participate in a SIG.
Investigators may use the WHI data independently of the WHI investigators. Please visit the NHLBI website for instructions to gain access to archived WHI data through the NHLBI BioLINCC.